Cell factory for human

Advanced Protein Technologies Corp

Research field

Core Technology

Core technology(Process development for recombinant protein)

rProtein Manufacturing AD-Pure™ System

rProtein Manufacturing AD-Pure™ System

Most of all natural proteins in E. coli proteome, have pI vales below 7.0. ADfuse technology leads to pI 8.5~10.0 by reconstruction of fusion protein, therefore we can recover highly purified proteins not only from E. coli natural proteins but also from endotoxin, DNA, and lipids at first capturing step.

On-column Cleavage (ADzyme™)

We conduct on- column cleavage of fusion protein instead of elution at 1st capturing step. Our ADzyme™ exactly cut off the fusion partner from the interested protein. We can usually obtain over 90% purity only at this 1st step of purification process.

Comparison for Technology
APTech’s proprietary process technology enables us to manufacture proteins 3~ 10 times cheaper than its peers.

ITEM
Host
Final purification hGH per fermentation broth
Purification Step
APTech
E.Coli
1.2g/L
2~3
Company A
E.Colii
0.3g/L
8~10
Company B
Yeast
0.15g/L
7~8

Contact research

Overview

Our Contract Research proceeds with three steps.
In Feasibility Study Step, we confirm whether or not our ADpure System™ is working for client’s proteins / peptides.
The following steps are Optimization of Process and Scale-up Studies.
At the completion of Contract Researh, client can choose license- in of the technology or contract manufacturing at APTech.

Procedure for CR

  • Pre Contract

    • Consulting
    • Signing a CDA & Proposal
  • Feasibility Study

    • Contract
    • Sample for Evaluation
    • Study and Report (2~3 months)
  • Optimization

    • Contract
    • Sample for Evaluation
    • Study and Report (2~3 months)
  • Scale-up

    • Contract
    • Sample for Evaluation
    • Study and Report (2~3 months()

List of Our Protein Products

Product name
EGF
VEGF
FGF-1
bFGF
IGF-1
PDGF-AA
GM-CSF
GLP1A
hGH
BMP2
ProteinA
ProteinG
Full name
Epidermal Growth Factor
Vascular Endothelial Growth Factor
Fibroblast Growth Factor-1
Basic Fibroblast Growth Factor
Insulin like Growth Factor-1
Platelet Derived Growth Factor-AA
Granulocyte Macrophage Colony Stimulating Factor
Glucagon like Peptide 1-A
human Growth Hormone
Bone Morphogenetic Protein 2
ProteinA
ProteinG
Supply Unit
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